CFA crews were called to the fire at the single storey weatherboard home just after 10.30am in Boort-Wedderburn Road.
The firefighters were able to contain the fire to the kitchen and lounge room area which is where the fire started.
The occupants weren't home at the time but their two dogs were inside the house. They were rushed to the vets but the extent of their injuries is unknown.
Support services such as the Red Cross were called in to assist the occupants.
The cause of the fire is still being investigated but it is not suspicious.
Firefighters from Boort, Korong Vale, Mysia and Wedderburn attended the fire.